The West Indies and England head to Barbados for the second test after the first match ended in a draw, on Saturday.
Resuming the day on 217-4 in their second innings, England declared on 349-6, setting the West Indies an improbable 286 runs from 71 overs.
Joe Root notched his 24th test century with 109 after resuming on 84. Zak Crawley top-scored with 121 after resuming on 117. Alzarri Joseph claimed 3-78 and Kemar Roach 2-53 for the Caribbean bowlers.
The hosts needing to bat 71 overs to save the test, saw openers Kraigg Brathwaite and John Campbell posting 59 for the first wicket when Brathwaite fell for 33.
The fall of Campbell for 22, Shamarh Brooks 5, and Jermaine Blackwood 2, saw the Windies slipped to 67-4.
However, Man of the Match Nkrumah Bonner and former captain Jason Holder shared in an 80 run fifth wicket stand which took the Windies to 147-4 when England captain Joe Root accepted a drawn result with five balls to go.
Bonner finished with 38 from 138 balls and Holder 37 from 101. Jack Leach took 3-57 for the English.
Scores in the match: England 311 and 349-6 declared, the West Indies 375 and 147-4. The result means the West Indies have never lost a test to England in Antigua. The second test starts on Wednesday in Barbados.
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Edited by Jesus Chan
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